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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8508 | HDAC-IN-3 | GSK3117391A | HDAC |
HDAC-IN-3 (GSK3117391A) is a potent histone deacetylase (HDAC) inhibitor, and treatment chronic inflammatory disorders. | |||
T2078 | Fimepinostat | CUDC-907,PI3K/HDAC Inhibitor,CUDC 907 | Apoptosis , PI3K , HDAC |
Fimepinostat (CUDC 907) is an orally bioavailable inhibitor of both phosphoinositide 3-kinase (PI3K) class I and pan-histone deacetylase (HDAC) enzymes, with potential antineoplastic activity. Upon oral administration, C... | |||
T6S0033 | Crotonoside | Isoguanosine,2-HYDROXYADENOSINE | Others , FLT , HDAC |
1. Crotonoside (Isoguanosine) has much more active than adenosine in reducing the blood pressure in rabbits and cats, in decreasing the tone of isolated intestinal strips of the rabbit, guinea pig and hamster and in stim... | |||
T36575 | HDAC3 Inhibitor | ||
HDAC3 inhibitor is an allosteric inhibitor of histone deacetylase 3 (HDAC3; Ki = 0.16 nM). It is selective for HDAC3 over HDAC1 and HDAC2 (IC50s = 0.95, 11.81, and 95.45 nM, respectively, using recombinant HDACs). In add... | |||
T24131 | HDAC3-IN-T247 | HDAC3 inhibitor T247,HDAC3 inhibitor-T247,HDAC3 IN T247,T247 | Histone Demethylase , Antiviral |
HDAC3-IN-T247 (HDAC3 inhibitor T247) is a selective and potent histone deacetylase 3 (HDAC3) inhibitor with anticancer and antiviral activities.HDAC3-IN-T247 induces NF-κB acetylation in human colon cancer HCT116 cells i... | |||
T24132 | HDAC3-IN-T326 | HDAC3 inhibitor-T326,T326,HDAC3 IN T326,HDAC3 inhibitor T326,HDAC3INT326 | |
HDAC3-IN-T326 is a potent and selective HDAC3 inhibitor that acts by increasing NF-κB acetylation and activating HIV gene expression in latent HIV-infected cells. | |||
T2025 | HDAC-IN-7 | HBI-8000,CS055,Chidamide impurity | HDAC |
HDAC-IN-7 (HBI-8000) (Chidamide impurity) is an impurity of Chidamide. Chidamide is a potent and orally bioavailable inhibitor of HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10). | |||
T3193 | Pimelic diphenylamide 106 | Histone Deacetylase Inhibitor VII,TC-H 106,RGFA-8 | HDAC |
Pimelic diphenylamide 106 (RGFA-8) is a slow, tight-binding inhibitor of class I HDAC (with IC50 values of 150 nM , 760 nM and 370 nM for HDAC 1, 2, and 3, respectively), showing no activity against class II HDACs. | |||
T73515 | MC2590 | Apoptosis , HDAC | |
MC2590 is a potent and selective histone deacetylase (HDAC) inhibitor that inhibits HDAC1-3, -6, -8, and -10 activities, induces cell cycle arrest, and promotes apoptosis. | |||
T10245 | ACY-957 | HDAC Inhibitor C001 | HDAC |
ACY-957 (HDAC Inhibitor C001) is an orally active and selective inhibitor of HDAC1 and HDAC2 (IC50s: 7 nM, 18 nM, and 1300 nM against HDAC1/2/3) and shows no inhibition on HDAC4/5/6/7/8/9. | |||
T1888 | Tacedinaline | Acetyldinaline,N-acetyldinaline,PD-123654,CI994,Goe-5549 | Apoptosis , HDAC |
Tacedinaline (CI994) is a selective class I HDAC inhibitor with potential antineoplastic activity. | |||
T2512 | Mocetinostat | MGCD0103,MG0103 | Apoptosis , HDAC , Autophagy |
Mocetinostat (MG0103) is an orally available HDAC inhibitor with most potency for HDAC1 (IC50: 0.15 μM), 2- to 10- fold selectivity against HDAC2/3/11. | |||
T0431 | Abexinostat | CRA 24781,PCI24781,PCI-24781,PCI 24781,CRA 024781 | HDAC |
PCI-24781 (Abexinostat (PCI24781)) is a new pan-HDAC inhibitor mainly targeting HDAC1 (Ki: 7 nM), also have moderate inhibitory for HDACs 2, 3, 6, and 10 and greater than 40-fold selectivity against HDAC8. Phase 1/2. | |||
T4481 | Tucidinostat | HBI-8000,Chidamide,CS 055 | HDAC |
Tucidinostat (Chidamide) is an effective and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, less active on HDAC8/11 (IC50: 733/432 nM), and sho... | |||
T4477 | Domatinostat tosylate | 4SC-202 tosylate,4SC-202 | Apoptosis , HDAC |
Domatinostat tosylate (4SC-202) is a selective inhibitor of class I HDAC for HDAC1/2/3 (IC50: 1.20/1.12/0.57 μM). It also displays inhibitory activity against Lysine-specific demethylase 1 (LSD1). | |||
T9041 | AES-350 | Apoptosis , HDAC | |
AES-350 is a potent and orally active HDAC6 inhibitor(IC50 and a Ki of 0.0244 μM and 0.035 μM, respectively). It is also against HDAC-3, -8, and -11 in an enzymatic activity assay with IC50 values of 0.187 μM, 0.245 μM, ... | |||
T1583 | Vorinostat | MK0683,suberoylanilide hydroxamic acid,SAHA | Apoptosis , Mitophagy , Virus Protease , HDAC , Autophagy |
Vorinostat (SAHA) is a pan-histone deacetylase (HDAC) inhibitor (IC50=10 nM) with inhibitory activity against HDAC1/2/3/6/7/11. Vorinostat has antitumor activity, induces cell differentiation, blocks the cell cycle and i... | |||
T6865 | Quisinostat dihydrochloride | Quisinostat 2HCl,Quisinostat (JNJ-26481585) 2HCl,JNJ26854165(Quisinostat) 2HCl,JNJ-26481585 2HCl | Apoptosis , HDAC , Autophagy |
Quisinostat dihydrochloride (JNJ26854165(Quisinostat) 2HCl) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a cell-free assay, modest potent to HDACs 2, 4, 10, and 11; g... | |||
T6055 | Quisinostat | JNJ-26481585 | Apoptosis , HDAC , Autophagy |
Quisinostat (JNJ-26481585) (JNJ-26481585) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM, modest potent to HDACs 2, 4, 10, and 11; greater than 30-fold selectivity against... | |||
T3205 | UF010 | HDAC | |
UF010 is a potent and selective HADC inhibitor with IC50 ~0.06 μM, 0.1 μM, 0.5 μM and 1.5 μM for HDACs 3, 2, 1 and 8, respectively. |